From eScan Wiki
Can MWAV toolkit clean the system infected with conficker/downadup virus?
Solution
Yes. The latest version of MWAV toolkit will clear the infections of Conficker/Downadup virus. But before starting the scan make sure your OS is updated with the hotfix (KB-958644) provided by Microsoft to fix the vulnerability exploited by this virus:
For Windows XP [for Windows XP)]
For Windows 2000 http://www.microsoft.com/downloads/details.aspx?familyid=E22EB3AE-1295-4FE2-9775-6F43C5C2AED3&displaylang=en|(KB-958644 for Windows 2000)]]
For Windows 2003 http://www.microsoft.com/downloads/details.aspx?FamilyID=f26d395d-2459-4e40-8c92-3de1c52c390d&displaylang=en|(KB-958644 for Windows XP)]]
For the latest download link for MWAV toolkit click on the below link.
Download Link for MWAV Toolkit
After applying the patches you can scan the machine with the latest MWAV.